diff --git a/docs/options.md b/docs/options.md
index 90f9015e..e0012cee 100644
--- a/docs/options.md
+++ b/docs/options.md
@@ -482,6 +482,11 @@ uv currently does not support iOS or musllinux on s390x, ppc64le and riscv64.
 You can also use the `uv` backend directly; though currently multiple output
 files (from workspaces) are not supported.
 
+!!! note
+    There is currently a compatibility issue between GraalPy and uv. If you
+    are building GraalPy wheels, use `build` or `pip` as the build frontend
+    instead of `build[uv]` or `uv`.
+
 On Android and Pyodide, the "pip" frontend is not supported.
 
 You can specify extra arguments to pass to the build frontend using the
diff --git a/test/conftest.py b/test/conftest.py
index ad8ccff1..2a80e770 100644
--- a/test/conftest.py
+++ b/test/conftest.py
@@ -13,6 +13,7 @@ from cibuildwheel.selector import EnableGroup
 from cibuildwheel.typing import PLATFORMS
 from cibuildwheel.venv import find_uv
 
+from . import utils
 from .utils import DEFAULT_CIBW_ENABLE, EMULATED_ARCHS, get_platform
 
 
@@ -164,7 +165,7 @@ def build_frontend_env_nouv(request: pytest.FixtureRequest) -> dict[str, str]:
 
 
 @pytest.fixture(params=["pip", "build", "build[uv]", "uv"])
-def build_frontend_env(request: pytest.FixtureRequest) -> dict[str, str]:
+def build_frontend_env(request: pytest.FixtureRequest) -> Generator[dict[str, str], None, None]:
     frontend = request.param
     marks = {m.name for m in request.node.iter_markers()}
     if "android" in marks:
@@ -186,7 +187,17 @@ def build_frontend_env(request: pytest.FixtureRequest) -> dict[str, str]:
     if uv_path is not None and frontend == "build" and platform not in {"android", "ios"}:
         pytest.skip("No need to check build when uv is present")
 
-    return {"CIBW_BUILD_FRONTEND": frontend}
+    # temporary workaround: uv doesn't work with graalpy yet
+    uses_uv = "uv" in frontend
+    env: dict[str, str] = {"CIBW_BUILD_FRONTEND": frontend}
+    if uses_uv:
+        utils.include_graalpy_in_expected_wheels = False
+        env["CIBW_SKIP"] = "gp*"  # skip graalpy when using uv, until uv supports it
+    try:
+        yield env
+    finally:
+        if uses_uv:
+            utils.include_graalpy_in_expected_wheels = True
 
 
 @pytest.fixture
diff --git a/test/utils.py b/test/utils.py
index 6acdc804..bb599abd 100644
--- a/test/utils.py
+++ b/test/utils.py
@@ -28,6 +28,10 @@ GRAALPY_ARCHS = ["x86_64", "AMD64", "aarch64", "arm64"]
 
 SINGLE_PYTHON_VERSION: Final[tuple[int, int]] = (3, 12)
 
+# temporary workaround: set by build_frontend_env fixture to skip graalpy
+# when uv is the build frontend (compatibility issue between graalpy and uv)
+include_graalpy_in_expected_wheels: bool = True
+
 _AARCH64_CAN_RUN_ARMV7: Final[bool] = Architecture.aarch64.value not in EMULATED_ARCHS and {
     None: Architecture.armv7l.value not in EMULATED_ARCHS,
     CIProvider.travis_ci: False,
@@ -305,7 +309,7 @@ def _expected_wheels(
                 "pp311-pypy311_pp73",
             ]
 
-        if EnableGroup.GraalPy in enable_groups:
+        if EnableGroup.GraalPy in enable_groups and include_graalpy_in_expected_wheels:
             python_abi_tags += [
                 "graalpy311-graalpy242_311_native",
                 "graalpy312-graalpy250_312_native",